RPACT Vignettes
In summary, the RPACT Vignettes are a curated collection of practical examples and use cases designed to guide users in utilizing the rpact package for adaptive clinical trial design and analysis in R. Accessible at rpact.org/vignettes, these vignettes serve as comprehensive tutorials, covering a wide array of topics pertinent to sequential and adaptive experiments.
Upon visiting the website, readers will encounter vignettes categorized into various sections, including:
Getting Started: Introduces the basics of the rpact package, offering step-by-step tutorials for newcomers.
Planning: Focuses on designing trials, encompassing aspects like group sequential boundaries, sample size calculations, and planning for different endpoints such as binary, continuous, and survival data.
Analysis: Provides insights into analyzing trial data, including methods for continuous data with covariates, multi-arm designs, and survival endpoints.
Power Simulation: Demonstrates how to perform power simulations for various trial designs, aiding in the assessment of statistical power under different scenarios.
Utilities: Offers guidance on auxiliary functions within rpact, such as creating summaries and generating plots to visualize data and results.
Each vignette is authored by experts in the field and includes publication dates, ensuring users have access to up-to-date information. For instance, the Step-by-Step rpact Tutorial by Daniel Lakens, Friedrich Pahlke, and Gernot Wassmer, published on March 25, 2025, provides an in-depth walkthrough for designing sequential and adaptive clinical trials using rpact.
In summary, the RPACT Vignettes website is an invaluable resource for both novice and experienced users seeking practical guidance on implementing adaptive clinical trial designs using the rpact package.