R Package crmPack
Open Source
R Package
Software
Clinical Trials
GxP
The comprehensive validated, open source, free-of-charge R software package for dose escalation trial design, simulation and analysis.
crmPack is a comprehensive open source, free-of-charge R software package for:
- Dose escalation trial planning
- Dose escalation trial design evaluation and simulation
- Dose escalation trial data analysis
Functional Range
- Dose escalation trial design, simulation and analysis
- Binary, time-to-event, dual efficacy/safety, ordinal outcomes
- Backfill cohorts
- >15 different models
- >14 different recommendation options
- >19 different stopping rules
- >9 cohort size rules
- >9 increment rules
- Reporting functionality (using knitr)

More high quality graphics produced by crmPack can be found in the gallery.
Installation
Install the latest CRAN release via
install.packages("crmPack")Development version
To use a feature from the development version, you can install the development version of crmPack from GitHub.
# install.packages("pak")
pak::pak("openpharma/crmPack")Documentation
The documentation is hosted at crmPack.org
Vignettes
The vignettes are hosted at crmPack.org/vignettes
